Risk factors

Chronic exposure to estrogen increases the risk for developing the disease and estrogen often affects tumour growth.

The following factors increase estrogen exposure:
Early menarche (<12 years)

Hormone replacement therapy (HRT) with exogenous estrogen (i.e. without progesterone).

Late menopause (after age 52)

Oestrogen-secreting tumor such as Granulosa cell tumour

Nulliparity or low parity

Obesity

Age (more common after age 50)

Personal history of breast, colorectal, or ovarian cancer

Prior pelvic radiation therapy

Race, Endometrial cancer is more common in Caucasian women

Presence of precancerous lesions such as Endometrial hyperplasia